In Japan, where fugu is so popular, chefs undergo a state-required licensing program. It’s because specialized fugu chefs know how to safely filet this culinary delight. So why are powerfully poisonous pufferfish such a preferred palatable pleasure? That’s equivalent to 10 nanograms, which is an amount impossible to see with the naked eye. Injecting 1 microdot of pure tetrodotoxin will kill the average-sized human. In fact, tetrodotoxin is far more lethal than venom found in the common death adder and the notorious taipan snake. Tetrodotoxin is the world’s deadliest substance by volume next to anthrax and a chemical inside the tropical cone snail. It’s 1,200 times more powerful than potassium cyanide which the Nazis used in their poison pills. What makes pufferfish so toxic is tetrodotoxin. Hundreds more become seriously ill and only bounce back through immediate medical intervention. Pufferfish death statistics are hard to nail down, but the World Health Organization and an article in National Geographic confirm at least 50 people expire every year after ingesting neurotoxins found in pufferfish livers, ovaries, testicles, intestines and skin. ![]() Most shark victims are seriously injured like having an arm or leg torn apart, yet somehow survive. Sharks kill an average of 5 people each year worldwide, although statistics show at least 80 violent human to shark encounters happen annually. ![]() And they do it a lot slower and far more viciously. Also called blowfish and sunfish, these sashimi delicacies known as fugu kill 10 times more people per year than sharks. ![]() They’re dangerous, all right, but the deep’s deadliest distinction goes to the cute little pufferfish you remember from Disney’s Little Mermaid. Most folks think great white, tiger and mako sharks are the world’s most deadly fish.
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